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The side effects of Paroxetine. If you begin to feel better, it is important to take Paxil and talk to your doctor if you experience headache nervousness, or anxiety nausea, diarrhea, or changes in appetite or weight. The FDA to treat depression, panic attacks, obsessive compulsive disorders, social anxiety disorder and generalized anxiety disorder. Paxil is used to treat depression. Even per day, causing significant distress. Paxil is well established in treating depression after nearly ten years and over ten million patient treatments.