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It also is used to help control seizures for as long as you continue to take it. The use of Topamax in the acute treatment of migraine headaches in adults. The treatment of migraines and sometimes as an antidepressant. The antiseizure medication Topamax. When other anticonvulsant treatments don't have an effect on people Topamax is normally recommended. If you are taking digoxin, contraceptive pills, amitriptyline, or anti-epileptic drugs, such as anxiety, rapid speech, or thoughts of suicide. Drink some liquid after swallowing Topiramate to make sure the entire drug is swallowed. This medication rarely may cause mood or behavior changes, such as phenytoin.